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The lower levels of body weight gain in our study may have been the result of investigators warning parents about this side effect.

Risperidone in Children and Adolescents with Conduct Disorder: A Single-Center, Open-Label Study

J Child Adolesc Psychopharmacol. Data were analyzed with the Statistical Package for the Social Sciences version The convergent validity of the scale was demonstrated by the relationship between the Turkish form of the ISMI and various criteria scales.

Most importantly, this was an open-label trial without a placebo-control group. The results of our study should be interpreted cautiously because of several limitations.

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Although all patients exhibited mild sedation in the beginning of the study, this adverse event was transitory. The children who were diagnosed with CD in the same way by both investigators were included in the study.

Patients found to have extrapyramidal symptoms were to be treated with benztropine. The mean SD full-scale IQ for the group was Recruitment and Screening Phase Recruitment and screening procedures were designed to collect a carefully diagnosed sample of children and adolescents with severe CD.

Sleep duration was monitored by parental observation, with a mean sleep increase of 0. In general, risperidone was well tolerated.


The mean SD dosage of risperidone at the end of week 8 was 1. Twenty-one children and adolescents 17 boys and 4 girls with a mean SD age of Twenty of the 21 varna completed the 8-week study period. Design and Medication The patients were treated with risperidone in vagan open-label fashion for 8 weeks, starting at a daily dosage of 0. Pilot trial and follow-up. Twenty-one patients were screened for the study.


Turgay et al 8 conducted a double-blind, placebo-controlled study of children with severe CD and mental retardation. Prog Neuropsychopharmacol Biol Psychiatry. After a 6-week trial of risperidone versus placebo, they found that risperidone was significantly more effective than placebo in reducing Nisonger Child Behavior Rating Form 5 conduct problem subscale scores. All patients underwent a complete review of current health status, which included a careful medical history.

Furthermore, patients were included only if they had been found to be refractory to methylphenidate therapy prior to this study. Reports from studies of risperidone in autistic children and adolescents also have shown that risperidone is a beneficial agent in treating conduct problems.

Lower scores reflect reduced psychopathology and greater therapeutic effectiveness. However, the beneficial effects of risperidone on inattention must be regarded as a tentative hypothesis until additional controlled studies have shown that risperidone is effective in improving inattention in children and adolescents with CD.

How does Europe PMC derive its citations network? In the light of the findings, it was concluded that the Turkish version of ISMI could be used as a reliable and valid tool in assessing internalized stigma of the Turkish psychiatric patients. Antipsychotic drugs are prescribed for as many as half of pediatric psychiatric inpatients and one third of pediatric psychiatric outpatients.


Published by Elsevier Inc. Rating scale to assess depression in school aged children. Therefore, no patient required treatment with benztropine.

Risperidone for young children with mood disorders and aggressive behavior. Conduct disorder CD is one of the most common psychiatric disorders in childhood and adolescence. This article has vaarn cited by other articles in PMC. Risperidone is one of the most commonly used atypical antipsychotic drugs in the treatment of children and adolescents. Risperidone is one of the most commonly used atypical antipsychotic drugs used in the treatment of children and adolescents.

Recruitment and screening procedures were designed to collect a carefully diagnosed sample of children and adolescents with severe CD. Also, a zzmi improvement was found in the ratings of severity of illness after 8 weeks of treatment on the CGI severity of illness subscale.

These symptoms are often accompanied by hyperactivity, impulsive behavior, explosiveness, cognitive and learning problems, azmmi poor social skills. Diagnostic and Statistical Manual of Mental Disorders. Please review our privacy policy. Instruments Three instruments were used to screen patients for this study. Gene Ontology GO Terms. Harcourt Brace; New York: Author information Copyright and License information Disclaimer. No severe adverse events were reported.