Co-processed excipients have been developed to handle changes in the physical properties of particles at sub-particle levels. By co-processing two excipients. A co-processed excipient is any combination of 2 or more excipients obtained by physical co-processing that does not lead to the formation of. co-processed excipients ppt. 1. 1; 2. CO-PROCESSED Presented by- Under the guidance ofMr. Bhaskar N. Bangar Dr. N. H. Aloorkar.
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Coprocessed excipient having good excipiennts ability is an important requirement for a direct compression excipient.
Crystal engineering and particle design for the powder compaction process. The simplicity and low capital investment of the direct-compression process have positioned it as a preferred alternative.
A comparison was made between coprocessed mucilage and coprocessed Sodium Starch Glycolate SSG which was prepared using similar method described above. The development of new grade of excipient is time consuming and lengthy process and requires regulatory approval as well. Evaluation coprocsesed ludipress as a multipurpose excipients for direct compression part I: The composition of the tablets was represented in Table 1. Powder flow depends on 3 general areas: US Pharmacopoeial Convention Inc.
It indicates that irrespective of concentration of polymer, this formulation was able to retain its stability. The results were given in Table 2. Studies on direct compression of xecipients.
Preparation of mouth dissolving tablet As given in Table 5, Terbutaline sulphate and coprocessed superdisintegrant were individually coproceszed and mixed thoroughly for about 5 min. Characterization of mucilage The mucilage which was isolated from the seeds of Ocimum bascilium was evaluated for flow properties, Loss on drying and swelling index.
It also acts as a buffering agent and as a dissolution aid in dispersible tablets. The bulk density was calculated by the formula: In addition, Mannitol is non-hygroscopic and may thus be used with moisture-sensitive ingredients.
To overcome these problems, the functionality of excipients can be improved by either developing new grades of excipients or modification of existing excipients. The different evaluation parameters of tablet like weight variation, hardness, friability, disintegration time, drug content, drug release etc.
For this purpose, a beaker was filled with 10 ml of water. Inhibition of the enzyme decreases de novo cholesterol synthesis, increasing low-density lipoprotein LDL receptors on hepatocytes. Formulated mouth dissolving tablets were characterised for physicochemical parameters like hardness, friability, weight variation, disintegration time, drug content and in vitro drug release behaviour. They are highly safe, stable, biocompatible, cheap, easily available, chemically inert, nontoxic and biodegradable in nature [ 7 ].
Kawakita plots were constructed from the formula: The direct compression technique involves the compression of a dry blend of powders that comprises drugs and various xoprocessed. A review of co-processed directly compressible excipients. In this study, acacia and calcium carbonate CaCO 3 were used to prepare a co-processing excipient suitable for the preparation of atorvastatin calcium tablets.
The mucilage was added to the CaCO 3 exxipients a damp mass was obtained. Diversity of their applications such as diluents, binders, disintegrants in tablet make them as alternative to synthetic excipients.
The properties are evaluated by Hausner’s ratio and Carr’s index values. Coprpcessed and Kawakita analysis of granules of the crude leaves extract of vernoniagalamensis prepared using poly vinyl pyrrolidone as binder. The tablet was put in the beaker and whole assembly was gently stirred, the time for the tablet to completely disintegrate into fine particles was noted [ 16 ].
Hence, this study involves both advantages of wet granulation and direct compression as atorvastatin calcium is very slightly soluble in water. Kawakita plots were constructed from the formula:. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. From Inactive ingredients to pharmaceutical excipients. Dinge A, Nagarsenker M Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity.
Powder characteristics and tableting properties. The main objective of this work was to evaluate novel natural superdisintegrant as coprocessed ready to use excipient for direct compression in the development of mouth dissolving formulation.
The tablets were prepared by direct compression method and the physical properties of tablets such as hardness, friability and dissolution profiles of tablets were evaluated. However, the main disadvantage is excpiients, in preparation of new formulations, the fixed proportion of the co-processed excipients is excioients be used to get synergistic effect which is not possible in every case. Disintegration time and in vitro drug release was done by in house method.
Calcium carbonate CaCO 3 is mainly used as a tablet diluent. Terbutaline sulphate is most commonly used drug in the treatment of asthma. The powdered mucilage was stored in desiccator until further use.
fxcipients The functionality of excipients means improvement in flow properties, compressibility, and better dilution potential. Mucilage exhibited disintegration within 8 sec at the concentration of 1 gm: In coprocessing the substance interacted at sub particle level that comprises the particle shape, size that gives improved eexcipients property. In the present study an attempt has been made to evaluate Ocimum bascilium mucilage coprocessed with Mannitol as a novel super disintegrant.
National Center for Biotechnology InformationU. A beaker was filled with 10 ml of water.